NICE® Gives You An Accurate Insight Into Your Pregnancy

From a simple blood draw as early as 10 weeks into your pregnancy, NICE® screens for the most common chromosomal abnormalities that can affect your developing baby’s future. This test is done with little or no risk to your pregnancy.

Overview
  • A simple blood test to screen for chromosomal abnormalities of the developing baby. Carries little or no risk to your pregnancy.
  • Can be performed as early as on the 10th week of pregnancy. Twin pregnancy can be tested.
  • Employs Whole Genome Sequencing method for comprehensive coverage of all chromosomes.
  • More than 99% accuracy rate.
  • Can be performed as early as 10 weeks. Pregnancies with twins can be accepted.
  • Option to know your baby’s gender.
  • Tested by internationally certified laboratory in South Korea.
  • 2 panels available to detect up to 10 conditions. Option to know your baby’s gender.
  • Up to US$300 confirmatory testing subsidy for patients detected with high risk of chromosomal abnormalities.
Conventional Prenatal Tests
vs
NICE® NIPT

Conventional maternal marker-based prenatal tests such as triple tests, quad tests and integrated tests carry a high false positive rate of 5% or more. This means that of those who were diagnosed as high risk through these tests, only 2 to 3 percent of them actually have Down syndrome. The rest of the group are perfectly normal but were misdiagnosed as part of the high risk group.
More accurate test reduce need for unnecessary invasive prenatal test
As high risk group patients are usually required to go through risky invasive test such as amniotic fluid test for confirmation, which exposes them to the risk of side effects including miscarriage, choosing a more reliable and accurate test will spare expectant mothers from unnecessary agony and anxiety. The table below compares the various prenatal tests available in the market today.
NICE®Conventional Serum TestsConfirmatory Tests
Detection Rate (T21)>99%80% – 95%99.99%
False Positive Rate (T21)1.49%3-5%less than 1%
Possible riskNo (non-invasive)No (non-invasive)Yes (invasive)
Specimen10ml of blood5ml of bloodAmniotic fluid or chorionic cells
Test periodAs early as 10 weeks10- 22 weeks10 – 20 weeks
Test methodNext generation sequencingSerum biochemical markersCultivation using amniotic fluid or chorionic cells
Turnaround time10 – 14 working days4 – 5 weeks 2 – 3 weeks
Source:

  1. Practice Bulletin No. 163: Screening for Fetal Aneuploidy; American college of Obstetrics & Gynaecologists. 127(5):e123–e137, May 2016.
  2. Kim MJ, Chang HK, Kim DI, Hee SU, Park S, Kim JH, Bae JS, Lee MH, Lee MS. Validation of fetus aneuploidy in 221 Korean clinical samples using non-invasive chromosome examination; J Genet Med 2015;12(2):79-84, May 2015.
  3. Non-Invasive Prenatal Testing (NIPT) Factsheet; National Coalition for Health Professional education in Genetics, 21 November 2012.
Enroling NICE® NIPT

NICE® NIPT must be prescribed by your obstetrician who will explain the details about NIPT to ensure the test is suitable for you.

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